An update on current and emerging treatments for pulmonary arterial hypertension in childhood and adolescence.

Details

Serval ID
serval:BIB_7973BAF1AECB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
An update on current and emerging treatments for pulmonary arterial hypertension in childhood and adolescence.
Journal
Expert review of respiratory medicine
Author(s)
Wacker J., Weintraub R., Beghetti M.
ISSN
1747-6356 (Electronic)
ISSN-L
1747-6348
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
13
Number
2
Pages
205-215
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Pulmonary hypertension is a severe condition that can develop during childhood due to several different etiologies. During the last two decades, based on a better understanding of the underlying pathobiology leading to pulmonary arterial hypertension, targeted therapies have been developed and have improved the dreadful prognosis of the condition. However, curative therapy remains elusive. Areas covered: In this article, we will review the currently available drugs in pediatric pulmonary arterial hypertension and discuss the recommended management strategies. Expert commentary: Most of the drugtrials in pulmonary hypertension have been performed in adults, with extrapolation of the results to children. Most of the pediatric studies are non-controlled. The rarity of the disease and the lack of identifiable pediatric treatment goals and satisfactory trial end-points could explain the paucity of specific pediatric studies. An evolution has been made in the last few years regarding the treatment strategy of pulmonary arterial hypertension, with evidence that early combination therapy with at least two pulmonary vasodilators was beneficial on the survival. Children with pulmonary hypertension should be referred to experienced centers early, to benefit from a comprehensive initial assessment. Serial clinical and hemodynamic re-evaluation should assess treatment response and guide potential change in therapy.
Keywords
Adolescent, Antihypertensive Agents/therapeutic use, Calcium Channel Blockers/therapeutic use, Child, Humans, Hypertension, Pulmonary/drug therapy, Prognosis, Vasodilator Agents/therapeutic use, paediatrics, pulmonary arterial hypertension, pulmonary vasodilators
Pubmed
Web of science
Create date
14/01/2019 9:42
Last modification date
21/08/2019 5:35
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