The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Details
Serval ID
serval:BIB_796365D38E1A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Journal
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
11/04/2023
Peer-reviewed
Oui
Volume
56
Number
4
Pages
813-828.e10
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
T cell factor 1 (Tcf-1) expressing CD8 <sup>+</sup> T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintenance of these stem-like CD8 <sup>+</sup> T cells (CD8 <sup>+</sup> SL) remain poorly defined. Studying CD8 <sup>+</sup> T cell differentiation in mice with chronic viral infection, we identified the alarmin interleukin-33 (IL-33) as pivotal for the expansion and stem-like functioning of CD8 <sup>+</sup> SL as well as for virus control. IL-33 receptor (ST2)-deficient CD8 <sup>+</sup> T cells exhibited biased end differentiation and premature loss of Tcf-1. ST2-deficient CD8 <sup>+</sup> SL responses were restored by blockade of type I interferon signaling, suggesting that IL-33 balances IFN-I effects to control CD8 <sup>+</sup> SL formation in chronic infection. IL-33 signals broadly augmented chromatin accessibility in CD8 <sup>+</sup> SL and determined these cells' re-expansion potential. Our study identifies the IL-33-ST2 axis as an important CD8 <sup>+</sup> SL-promoting pathway in the context of chronic viral infection.
Keywords
Animals, Mice, Alarmins/metabolism, CD8-Positive T-Lymphocytes, Interleukin-1 Receptor-Like 1 Protein/metabolism, Interleukin-33/metabolism, Lymphocytic Choriomeningitis/immunology, Lymphocytic choriomeningitis virus, Mice, Inbred C57BL, Persistent Infection, T Cell Transcription Factor 1/metabolism, CD8(+)SL, IL-33, T cell factor 1, Tcf-1, chronic viral infection, interleukin-33, lymphocytic choriomeningitis virus, stem-like CD8(+) T cells, type I interferon
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2023 14:30
Last modification date
17/11/2023 7:14