The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_796365D38E1A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Journal
Immunity
Author(s)
Marx A.F., Kallert S.M., Brunner T.M., Villegas J.A., Geier F., Fixemer J., Abreu-Mota T., Reuther P., Bonilla W.V., Fadejeva J., Kreutzfeldt M., Wagner I., Aparicio-Domingo P., Scarpellino L., Charmoy M., Utzschneider D.T., Hagedorn C., Lu M., Cornille K., Stauffer K., Kreppel F., Merkler D., Zehn D., Held W., Luther S.A., Löhning M., Pinschewer D.D.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
11/04/2023
Peer-reviewed
Oui
Volume
56
Number
4
Pages
813-828.e10
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
T cell factor 1 (Tcf-1) expressing CD8 <sup>+</sup> T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintenance of these stem-like CD8 <sup>+</sup> T cells (CD8 <sup>+</sup> SL) remain poorly defined. Studying CD8 <sup>+</sup> T cell differentiation in mice with chronic viral infection, we identified the alarmin interleukin-33 (IL-33) as pivotal for the expansion and stem-like functioning of CD8 <sup>+</sup> SL as well as for virus control. IL-33 receptor (ST2)-deficient CD8 <sup>+</sup> T cells exhibited biased end differentiation and premature loss of Tcf-1. ST2-deficient CD8 <sup>+</sup> SL responses were restored by blockade of type I interferon signaling, suggesting that IL-33 balances IFN-I effects to control CD8 <sup>+</sup> SL formation in chronic infection. IL-33 signals broadly augmented chromatin accessibility in CD8 <sup>+</sup> SL and determined these cells' re-expansion potential. Our study identifies the IL-33-ST2 axis as an important CD8 <sup>+</sup> SL-promoting pathway in the context of chronic viral infection.
Keywords
Animals, Mice, Alarmins/metabolism, CD8-Positive T-Lymphocytes, Interleukin-1 Receptor-Like 1 Protein/metabolism, Interleukin-33/metabolism, Lymphocytic Choriomeningitis/immunology, Lymphocytic choriomeningitis virus, Mice, Inbred C57BL, Persistent Infection, T Cell Transcription Factor 1/metabolism, CD8(+)SL, IL-33, T cell factor 1, Tcf-1, chronic viral infection, interleukin-33, lymphocytic choriomeningitis virus, stem-like CD8(+) T cells, type I interferon
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2023 14:30
Last modification date
17/11/2023 7:14
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