Molecular regulation of lymphangiogenesis.

Détails

ID Serval
serval:BIB_78F3634D7F3B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular regulation of lymphangiogenesis.
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Saharinen P., Petrova T.V.
ISSN
0077-8923 (Print)
ISSN-L
0077-8923
Statut éditorial
Publié
Date de publication
2004
Volume
1014
Pages
76-87
Langue
anglais
Résumé
The lymphatic vascular system is necessary for the return of extravasated interstitial fluid and macromolecules to the blood circulation, for immune defense, and for the uptake of dietary fats. Impaired functioning of lymphatic vessels results in lymphedema, whereas tumor-associated lymphangiogenesis may contribute to the spread of cancer cells from solid tumors. Recent studies have identified lymphatic molecular markers and growth factors necessary for lymphangiogenesis. In particular, lymphatic endothelial receptor tyrosine kinase VEGFR-3 and its ligands VEGF-C and VEGF-D play crucial roles in promoting lymphatic vascular growth both during development and in pathological conditions. Isolation of pure cultures of lymphatic and blood vascular endothelial cells and systematic characterization of their transcriptomes provide useful cell culture models and novel potential vascular markers and offer further insights into the lymphatic vascular biology. Ectopic expression of the lymphatic endothelial specific homeobox transcription factor Prox1 in blood endothelial cells results in a shift in the gene expression profile towards the lymphatic endothelial phenotype, demonstrating the plasticity of endothelial cells and offering the possibility of transcriptional reprogramming of vascular endothelial cells for future therapeutic applications.
Mots-clé
Animals, Gene Expression Regulation, Neoplastic, Humans, Lymphangiogenesis/physiology, Neoplasm Metastasis/physiopathology, Neoplasms/physiopathology
Pubmed
Web of science
Création de la notice
20/12/2012 16:48
Dernière modification de la notice
03/03/2018 18:30
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