Early disturbances of gamma band dynamics in mild cognitive impairment.

Details

Serval ID
serval:BIB_78E882A0D733
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early disturbances of gamma band dynamics in mild cognitive impairment.
Journal
Journal of Neural Transmission (vienna, Austria : 1996)
Author(s)
Missonnier P., Herrmann F.R., Michon A., Fazio-Costa L., Gold G., Giannakopoulos P.
ISSN
1435-1463[electronic], 0300-9564[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
117
Number
4
Pages
489-498
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Recent studies have indicated that gamma band oscillations participate in the temporal binding needed for the synchronization of cortical networks involved in short-term memory and attentional processes. To date, no study has explored the temporal dynamics of gamma band in the early stages of dementia. At baseline, gamma band analysis was performed in 29 cases with mild cognitive impairment (MCI) during the n-back task. Based on phase diagrams, multiple linear regression models were built to explore the relationship between the cognitive status and gamma oscillation changes over time. Individual measures of phase diagram complexity were made using fractal dimension values. After 1 year, all cases were assessed neuropsychologically using the same battery. A total of 16 MCI patients showed progressive cognitive decline (PMCI) and 13 remained stable (SMCI). When adjusted for gamma values at lag -2, and -3 ms, PMCI cases displayed significantly lower average changes in gamma values than SMCI cases both in detection and 2-back tasks. Gamma fractal dimension of PMCI cases displayed significantly higher gamma fractal dimension values compared to SMCI cases. This variable explained 11.8% of the cognitive variability in this series. Our data indicate that the progression of cognitive decline in MCI is associated with early deficits in temporal binding that occur during the activation of selective attention processes.
Pubmed
Web of science
Create date
06/04/2010 10:46
Last modification date
20/08/2019 14:35
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