Genome-wide association study of major recurrent depression in the U.K. population.

Détails

ID Serval
serval:BIB_78B6003ED828
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genome-wide association study of major recurrent depression in the U.K. population.
Périodique
American Journal of Psychiatry
Auteur(s)
Lewis C.M., Ng M.Y., Butler A.W., Cohen-Woods S., Uher R., Pirlo K., Weale M.E., Schosser A., Paredes U.M., Rivera M., Craddock N., Owen M.J., Jones L., Jones I., Korszun A., Aitchison K.J., Shi J., Quinn J.P., Mackenzie A., Vollenweider P., Waeber G., Heath S., Lathrop M., Muglia P., Barnes M.R., Whittaker J.C., Tozzi F., Holsboer F., Preisig M., Farmer A.E., Breen G., Craig I.W., McGuffin P.
ISSN
1535-7228[electronic], 0002-953X[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
167
Numéro
8
Pages
949-957
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
OBJECTIVE: Studies of major depression in twins and families have shown moderate to high heritability, but extensive molecular studies have failed to identify susceptibility genes convincingly. To detect genetic variants contributing to major depression, the authors performed a genome-wide association study using 1,636 cases of depression ascertained in the U.K. and 1,594 comparison subjects screened negative for psychiatric disorders. METHOD: Cases were collected from 1) a case-control study of recurrent depression (the Depression Case Control [DeCC] study; N=1346), 2) an affected sibling pair linkage study of recurrent depression (probands from the Depression Network [DeNT] study; N=332), and 3) a pharmacogenetic study (the Genome-Based Therapeutic Drugs for Depression [GENDEP] study; N=88). Depression cases and comparison subjects were genotyped at Centre National de Génotypage on the Illumina Human610-Quad BeadChip. After applying stringent quality control criteria for missing genotypes, departure from Hardy-Weinberg equilibrium, and low minor allele frequency, the authors tested for association to depression using logistic regression, correcting for population ancestry. RESULTS: Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. A meta-analysis of U.K. data with previously published results from studies in Munich and Lausanne showed some evidence for association near neuroligin 1 (NLGN1) on chromosome 3, but did not support findings at BICC1. CONCLUSIONS: This study identifies several signals for association worthy of further investigation but, as in previous genome-wide studies, suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.
Mots-clé
Colaus Study
Pubmed
Web of science
Création de la notice
30/06/2010 11:01
Dernière modification de la notice
20/08/2019 15:35
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