Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria.

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State: Public
Version: Final published version
Serval ID
serval:BIB_78967EA00471
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria.
Journal
Journal of Immunology Research
Author(s)
Colborn J.M., Ylöstalo J.H., Koita O.A., Cissé O.H., Krogstad D.J.
ISSN
2314-7156 (Electronic)
ISSN-L
2314-7156
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2015
Pages
162639
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cytokine, and inflammation-related genes (IL-1β, IL-6, TNF, and IFN-γ), which was more frequent with parasitemias >100,000 per μL and body temperatures ≥ 39°C. Apoptosis-related genes (Fas, BAX, and TP53) were upregulated acutely and for several days thereafter (days 1-3). In contrast, the expression of immune-modulatory (transcription factor 7, HLV-DOA, and CD6) and apoptosis inhibitory (c-myc, caspase 8, and Fas Ligand G) genes was downregulated initially and returned to normal with clinical recovery (days 7-10). These results indicate that the innate immune response, cytokine, and apoptosis pathways are upregulated acutely in uncomplicated malaria with concomitant downregulation of immune-modulatory and apoptosis inhibitory genes.
Keywords
Adolescent, Apoptosis/genetics, Case-Control Studies, Child, Child, Preschool, Cluster Analysis, Computational Biology, Female, Gene Expression, Gene Expression Profiling, Gene Regulatory Networks, Humans, Leukocytes, Mononuclear/immunology, Leukocytes, Mononuclear/metabolism, Malaria, Falciparum/genetics, Malaria, Falciparum/immunology, Male, Parasitemia, Reproducibility of Results, Temperature
Pubmed
Web of science
Open Access
Yes
Create date
03/11/2015 18:49
Last modification date
20/08/2019 14:35
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