Prospective association between adherence to the Mediterranean diet and hepatic steatosis: the Swiss CoLaus cohort study.

Details

Ressource 1Download: 33371031_BIB_78884F05CE35.pdf (764.87 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_78884F05CE35
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prospective association between adherence to the Mediterranean diet and hepatic steatosis: the Swiss CoLaus cohort study.
Journal
BMJ open
Author(s)
Khalatbari-Soltani S., Marques-Vidal P., Imamura F., Forouhi N.G.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
22/12/2020
Peer-reviewed
Oui
Volume
10
Number
12
Pages
e040959
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The Mediterranean diet has been promoted as a healthy dietary pattern, but whether the Mediterranean diet may help to prevent hepatic steatosis is not clear. This study aimed to evaluate the prospective association between adherence to the Mediterranean diet and risk of hepatic steatosis.
Population-based prospective cohort study.
The Swiss CoLaus Study.
We evaluated 2288 adults (65.4% women, aged 55.8±10.0 years) without hepatic steatosis at first follow-up in 2009-2012. Adherence to the Mediterranean diet was scaled as the Mediterranean diet score (MDS) based on the Mediterranean diet pyramid ascertained with responses to Food Frequency Questionnaires.
New onset of hepatic steatosis was ascertained by two indices separately: the Fatty Liver Index (FLI, ≥60 points) and the non-alcoholic fatty liver disease (NAFLD) score (≥-0.640 points). Prospective associations between adherence to the Mediterranean diet and risk of hepatic steatosis were quantified using Poisson regression.
During a mean 5.3 years of follow-up, hepatic steatosis was ascertained in 153 (6.7%) participants by FLI criteria and in 208 (9.1%) by NAFLD score. After multivariable adjustment, higher adherence to MDS was associated with lower risk of hepatic steatosis based on FLI: risk ratio 0.84 (95% CI 0.73 to 0.96) per 1 SD of MDS; 0.85 (0.73 to 0.99) adjusted for BMI; and 0.85 (0.71 to 1.02) adjusted for both BMI and waist circumference. When using NAFLD score, no significant association was found between MDS and risk of hepatic steatosis (0.95 (0.83 to 1.09)).
A potential role of the Mediterranean diet in the prevention of hepatic steatosis is suggested by the inverse association observed between adherence to the Mediterranean diet and incidence of hepatic steatosis based on the FLI. The inconsistency of this association when hepatic steatosis was assessed by NAFLD score points to the need for accurate population-level assessment of fatty liver and its physiological markers.
Keywords
epidemiology, hepatology, nutrition & dietetics, public health
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2021 9:27
Last modification date
30/04/2021 6:11
Usage data