Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.

Details

Serval ID
serval:BIB_7879BB243E97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H., Finke D.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
2014
Volume
111
Number
35
Pages
12835-12840
Language
english
Abstract
Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. ILC3s can take up latex beads, process protein antigen, and consequently prime CD4(+) T-cell responses in vitro. The cognate interaction of ILC3s and CD4(+) T cells leads to T-cell proliferation both in vitro and in vivo, whereas its disruption impairs specific T-cell and T-dependent B-cell responses in vivo. In addition, the ILC3-CD4(+) T-cell interaction is bidirectional and leads to the activation of ILC3s. Taken together, our data reveal a novel activation-dependent function of peripheral ILC3s in eliciting cognate CD4(+) T-cell immune responses.
Keywords
T-cell activation, antigen presentation
Pubmed
Web of science
Open Access
Yes
Create date
26/09/2014 8:21
Last modification date
20/08/2019 14:35
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