Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.

Détails

ID Serval
serval:BIB_7879BB243E97
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H., Finke D.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2014
Volume
111
Numéro
35
Pages
12835-12840
Langue
anglais
Résumé
Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. ILC3s can take up latex beads, process protein antigen, and consequently prime CD4(+) T-cell responses in vitro. The cognate interaction of ILC3s and CD4(+) T cells leads to T-cell proliferation both in vitro and in vivo, whereas its disruption impairs specific T-cell and T-dependent B-cell responses in vivo. In addition, the ILC3-CD4(+) T-cell interaction is bidirectional and leads to the activation of ILC3s. Taken together, our data reveal a novel activation-dependent function of peripheral ILC3s in eliciting cognate CD4(+) T-cell immune responses.
Mots-clé
T-cell activation, antigen presentation
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/09/2014 8:21
Dernière modification de la notice
20/08/2019 14:35
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