Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development.

Details

Serval ID
serval:BIB_786663D0DF8A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development.
Journal
Journal of Comparative Neurology
Author(s)
Bloch J., Kaeser M., Sadeghi Y., Rouiller E.M., Redmond D.E., Brunet J.F.
ISSN
1096-9861[electronic], 0021-9967[linking]
Publication state
Published
Issued date
2011
Volume
519
Number
4
Pages
775-789
Language
english
Notes
Publication types: Journal Article
Abstract
We have demonstrated that cortical cell autografts might be a useful therapy in two monkey models of neurological disease: motor cortex lesion and Parkinson's disease. However, the origin of the useful transplanted cells obtained from cortical biopsies is not clear. In this report we describe the expression of doublecortin (DCX) in these cells based on reverse-transcription polymerase chain reaction (RT-PCR) and immunodetection in the adult primate cortex and cell cultures. The results showed that DCX-positive cells were present in the whole primate cerebral cortex and also expressed glial and/or neuronal markers such as glial fibrillary protein (GFAP) or neuronal nuclei (NeuN). We also demonstrated that only DCX/GFAP positive cells were able to proliferate and originate progenitor cells in vitro. We hypothesize that these DCX-positive cells in vivo have a role in cortical plasticity and brain reaction to injury. Moreover, in vitro these DCX-positive cells have the potential to reacquire progenitor characteristics that confirm their potential for brain repair.
Pubmed
Web of science
Create date
10/03/2011 10:51
Last modification date
20/08/2019 14:35
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