Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).
Details
Serval ID
serval:BIB_77DC0B31FF93
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).
Journal
PloS one
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
18
Number
12
Pages
e0295325
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
Keywords
Infant, Newborn, Humans, Neonatal Sepsis/therapy, Research Design, Delphi Technique, Consensus, Outcome Assessment, Health Care/methods, Treatment Outcome, Systematic Reviews as Topic
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2023 16:57
Last modification date
08/08/2024 7:35