Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.

Détails

ID Serval
serval:BIB_77C04461F8A4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.
Périodique
Seminars in Immunology
Auteur(s)
Huang H.Y., Luther S.A.
ISSN
1096-3618 (Electronic)
ISSN-L
1044-5323
Statut éditorial
Publié
Date de publication
2012
Volume
24
Numéro
3
Pages
175-189
Langue
anglais
Résumé
Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery. More recently, IL-7 reporter mice and other approaches have led to the further characterization of the various stromal cell sources of IL-7 in secondary lymphoid organs (SLO) and other tissues. We will review these advances along with a discussion of the regulation of IL-7 and its receptor, and compare the biological effects IL-7 has on adaptive as well as innate immune cells in SLO. Finally, we will review the role of IL-7 in development of SLO and tertiary lymphoid tissues that frequently are associated with sites of chronic inflammation.
Mots-clé
Animals, Cell Lineage, Homeostasis, Humans, Inflammation/immunology, Interleukin-7/immunology, Lymphatic System/cytology, Lymphatic System/immunology, Receptors, Interleukin-7/immunology
Pubmed
Web of science
Création de la notice
07/12/2012 11:36
Dernière modification de la notice
03/03/2018 18:28
Données d'usage