Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours.

Détails

ID Serval
serval:BIB_77ABA632BC42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours.
Périodique
Histopathology
Auteur(s)
La Rosa S., Rigoli E., Uccella S., Novario R., Capella C.
ISSN
0309-0167 (Print)
ISSN-L
0309-0167
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
50
Numéro
5
Pages
597-606
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
AIM: The prognosis of well-differentiated pancreatic endocrine tumours (PETs) is difficult to establish on a histological basis. The expression of cytokeratin (CK19) has recently been proposed as an indicator of unfavourable outcome. However, this finding still needs to be verified and to be compared with more frequently used prognosticators such as proliferative indices, vascular and/or perineural invasion. The aim of this study was to evaluate the prognostic value of CK19 expression in PETs.
METHODS AND RESULTS: One hundred and forty-five PETs were studied using two different anti-CK19 monoclonal antibodies (BA17 and RCK108). The results were statistically compared with proliferation markers, vascular and perineural invasion and the presence of metastases. On univariate analysis, CK19 immunoreactivity correlated with prognosis only when it was detected with the RCK108 antibody and only in the whole group of PETs and in insulinomas. Conversely, it did not predict survival in non-functioning neoplasms. Ki67 index, mitotic count, vascular and perineural invasion were all statistically correlated with prognosis. On multivariate analysis, only the Ki67 index and metastases were independent prognosticators.
CONCLUSIONS: CK19 expression correlates with patient survival only when detected with the RCK108 antibody and mainly in insulinomas. Ki67 index and metastases represent the only two independent predictors of survival.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/metabolism, Carcinoma, Islet Cell/metabolism, Carcinoma, Islet Cell/mortality, Cell Proliferation, Child, Female, Humans, Immunoenzyme Techniques, Insulinoma/metabolism, Insulinoma/mortality, Islets of Langerhans/metabolism, Keratin-19/metabolism, Ki-67 Antigen/metabolism, Male, Middle Aged, Pancreatic Neoplasms/metabolism, Pancreatic Neoplasms/mortality, Prognosis, Survival Rate
Pubmed
Web of science
Création de la notice
06/09/2016 14:42
Dernière modification de la notice
20/08/2019 14:34
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