Mastocytose: quand faut-il y penser ? [Mastocytosis: when should it be considered?]

Détails

ID Serval
serval:BIB_779E1372EF6A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Mastocytose: quand faut-il y penser ? [Mastocytosis: when should it be considered?]
Périodique
Revue Médicale Suisse
Auteur(s)
Comte-Perret S., Bart P.A., Spertini F., Leimgruber A.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2009
Volume
5
Numéro
199
Pages
837-842
Langue
français
Notes
Titre traduit: [Mastocytosis: when should it be considered?] - Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Résumé
Mast cell disorders are defined by the accumulation of mast cells in one or more organ systems. Cutaneous forms are mainly observed in children whereas systemic forms are predominant in adults. Mast cells cause symptoms by the release of proinflammatory mediators or by infiltration of various organs. The measurement of serum tryptase has opened the possibility of screening for mastocytosis, which must be taken into consideration in case of severe anaphylactic reactions. Definite diagnosis is established based on a biopsy of skin or bone marrow. An activating mutation of stem cell factor receptor c-kit is often found. Treatment is based on control of the symptoms triggered by mast cell degranulation. Moreover, novel treatment options targeting mast cell proliferation become available for clinical use.
Pubmed
Création de la notice
18/05/2009 22:43
Dernière modification de la notice
03/03/2018 18:28
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