Study of antiatherogenic properties of indapamide in a pharmacologic model

Détails

ID Serval
serval:BIB_777E720F0564
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Study of antiatherogenic properties of indapamide in a pharmacologic model
Périodique
Journal of Cardiovascular Pharmacology
Auteur(s)
Lebrillant  E., Roulet  M. J., Robert  R., Schiavi  P., Guez  D., Jean  T.
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
22 Suppl 6
Pages
S53-6
Notes
Comparative Study
Journal Article
Résumé
A localized atheromatous plaque was induced in rabbits after transmural electrical stimulation of the carotid and a cholesterol-rich diet (1.33% cholesterol) for 4 weeks. This model was used to investigate the antiatherogenicity of indapamide. The treatment given per os started 14 days before the stimulation period. Animals were divided into six groups: group 1 (control) received gelatin 2%, group 2 received hydrochlorothiazide at 20 mg/kg/day, group 3 was treated with flunarizine at 25 mg/kg/day, and groups 4, 5, and 6 received indapamide at 0.3, 1, and 3 mg/kg/day, respectively. During the experimental period, all rabbits showed similar weight gain, regardless of the treatment. Image analysis showed an antiatherogenic effect for indapamide (0.3 mg/kg/day) characterized by a reduction in the number of cell layers (NCL; 10.5 +/- 1.8 vs. 18.0 +/- 2.9; p < 0.05) and in the intima/media area ratio (I/M; 17.5 +/- 4.5 vs. 42.7 +/- 7.0%; p < 0.01). Indapamide appeared to be more active than the reference drug flunarizine (NCL = 14.2 +/- 2.5, N.S.; I/M = 24.5 +/- 4.3, p < 0.05). The maximum effect occurred at the lowest dose tested (0.3 mg/kg/day). The reason for the loss of antiatherogenic activity of indapamide at higher doses is discussed. Hydrochlorothiazide did not show any effect on the formation of the atheromatous plaque.
Mots-clé
Animals Arteriosclerosis/*drug therapy/pathology Basement Membrane/drug effects Body Weight/drug effects Carotid Arteries/*drug effects/pathology Cell Division/drug effects Cholesterol, Dietary Disease Models, Animal Electric Stimulation Flunarizine/pharmacology Hydrochlorothiazide/pharmacology Image Processing, Computer-Assisted Indapamide/administration & dosage/*pharmacology/therapeutic use Male Rabbits Tunica Intima/drug effects
Pubmed
Web of science
Création de la notice
24/01/2008 21:33
Dernière modification de la notice
03/03/2018 18:27
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