Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery.

Détails

ID Serval
serval:BIB_7756A34E5AD8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery.
Périodique
British Journal of Anaesthesia
Auteur(s)
Licker M., Bednarkiewicz M., Neidhart P., Prêtre R., Montessuit M., Favre H., Morel D.R.
ISSN
0007-0912 (Print)
ISSN-L
0007-0912
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
76
Numéro
5
Pages
632-639
Langue
anglais
Résumé
We studied 22 patients undergoing aortic surgery, allocated randomly to receive, before induction of anaesthesia, a single i.v. dose of enalapril 50 micrograms kg-1 or saline. During infrarenal aortic cross-clamping, we observed similar reductions in oxygen uptake in the two groups, despite greater systemic oxygen delivery in enalapril-treated patients; angiotensin-converting enzyme inhibition prevented the reduction in cardiac output and attenuated the decrease in glomerular filtration. Changes in glomerular filtration secondary to aortic clamping were related positively to changes in renal plasma flow (r = 0.83 (saline group) and r = 0.65 (enalapril group)). Creatinine clearance on the first day after operation was significantly higher in the enalapril compared with the saline group. We conclude that enalapril pretreatment is effective in improving systemic oxygen delivery, renal plasma flow and glomerular filtration during aortic abdominal surgery.
Pubmed
Web of science
Création de la notice
16/12/2014 19:05
Dernière modification de la notice
03/03/2018 18:27
Données d'usage