The impact of DNA methylation in Alphaproteobacteria.

Détails

Ressource 1Télécharger: mmi.14079.pdf (253.05 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7732682E2002
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The impact of DNA methylation in Alphaproteobacteria.
Périodique
Molecular microbiology
Auteur(s)
Mouammine A., Collier J.
ISSN
1365-2958 (Electronic)
ISSN-L
0950-382X
Statut éditorial
Publié
Date de publication
10/2018
Peer-reviewed
Oui
Volume
110
Numéro
1
Pages
1-10
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Alphaproteobacteria include bacteria with very different modes of life, from free-living to host-associated and pathogenic bacteria. Their genomes vary in size and organization from single circular chromosomes to multipartite genomes and are often methylated by one or more adenine or cytosine methyltransferases (MTases). These include MTases that are part of restriction/modification systems and so-called orphan MTases. The development of novel technologies accelerated the analysis of methylomes and revealed the existence of epigenetic patterns in several Alphaproteobacteria. This review describes the known functions of DNA methylation in Alphaproteobacteria and also discusses its potential drawbacks through the accidental deamination of methylated cytosines. Particular emphasis is given to the strong connection between the cell cycle-regulated orphan MTase CcrM and the complex network that controls gene expression and cell cycle progression in Alphaproteobacteria.
Mots-clé
Alphaproteobacteria/genetics, Alphaproteobacteria/physiology, Cell Cycle/physiology, DNA Methylation/physiology, Epigenomics, Evolution, Molecular, Gene Expression Regulation, Bacterial/genetics, Genome, Bacterial/genetics, Methyltransferases/genetics, Methyltransferases/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/07/2018 15:24
Dernière modification de la notice
22/07/2019 6:12
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