Article: article from journal or magazin.
Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin.
Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.
DNA intercalating agents, daunorubicin, AFM, linking number, time-lapse imaging, drug development
Web of science
Last modification date