Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Effects of maternally administered drugs on the fetal and neonatal kidney.
Publication types: Journal Article ; Review Publication Status: ppublish
The number of pregnant women and women of childbearing age who are receiving drugs is increasing. A variety of drugs are prescribed for either complications of pregnancy or maternal diseases that existed prior to the pregnancy. Such drugs cross the placental barrier, enter the fetal circulation and potentially alter fetal development, particularly the development of the kidneys. Increased incidences of intrauterine growth retardation and adverse renal effects have been reported. The fetus and the newborn infant may thus experience renal failure, varying from transient oligohydramnios to severe neonatal renal insufficiency leading to death. Such adverse effects may particularly occur when fetuses are exposed to NSAIDs, ACE inhibitors and specific angiotensin II receptor type 1 antagonists. In addition to functional adverse effects, in utero exposure to drugs may affect renal structure itself and produce renal congenital abnormalities, including cystic dysplasia, tubular dysgenesis, ischaemic damage and a reduced nephron number. Experimental studies raise the question of potential long-term adverse effects, including renal dysfunction and arterial hypertension in adulthood. Although neonatal data for many drugs are reassuring, such findings stress the importance of long-term follow-up of infants exposed in utero to certain drugs that have been administered to the mother.
Adrenal Cortex Hormones/adverse effects, Anti-Bacterial Agents/adverse effects, Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Antihypertensive Agents/adverse effects, Antineoplastic Agents/adverse effects, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Immunosuppressive Agents/adverse effects, Infant, Newborn, Kidney/drug effects, Kidney/embryology, Kidney Diseases/chemically induced, Maternal Exposure/adverse effects, Pregnancy, Prenatal Exposure Delayed Effects/chemically induced, Tocolytic Agents/adverse effects
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