Heritability of left ventricular structure and function in Caucasian families.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_7686BC69DE77
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Heritability of left ventricular structure and function in Caucasian families.
Périodique
European Journal of Echocardiography
Auteur(s)
Jin Yu, Kuznetsova Tatiana, Bochud Murielle, Richart Tom, Thijs Lutgarde, Cusi Daniele, Fagard Robert., Staessen Jan A.
ISSN
1532-2114 (Electronic)
ISSN-L
1532-2114
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
12
Numéro
4
Pages
326-332
Langue
anglais
Résumé
AIMS: The aim of this study was to investigate the heritability as well as genetic and environmental correlations of left ventricular (LV) structural and functional traits in complex pedigrees of a Caucasian population. METHODS AND RESULTS: We randomly recruited 459 white European subjects from 52 families (50% women; mean age 45 years). LV structure was measured by M-mode and 2D echocardiography and LV function was measured by conventional Doppler and tissue Doppler imaging (TDI). Other measurements included blood pressure, anthropometric, and biochemical measurements. We estimated the heritability of LV traits while adjusting for covariables, including sex, age, body height and weight, systolic and diastolic blood pressures, and heart rate. With full adjustment, heritability of LV mass was 0.23 (P= 0.025). The TDI-derived mitral annular velocities Ea and Aa showed moderate heritability (h(2)= 0.36 and 0.53, respectively), whereas the mitral inflow A peak had weak heritability (h(2) = 0.25) and the E peak was not heritable (h(2) = 0.11). We partitioned the total phenotypic correlation when it reached significance, into a genetic and an environmental component. The genetic correlations were 0.61 between the E and Ea peaks and 0.90 between the A and Aa peaks. CONCLUSION: Our study demonstrated moderate heritability for LV mass as well as the mitral annular Ea and Aa peaks. We also found significant genetic correlations between the E and Ea peaks and between the A and Aa peaks. Our current findings support the ongoing research to map and detect genetic variants that contribute to the variation in LV mass and other LV structural and functional phenotypes.
Mots-clé
Adult, Anthropometry, Biological Markers/analysis, Blood Pressure, Echocardiography, Doppler, European Continental Ancestry Group/genetics, Female, Genotype, Humans, Hypertrophy, Left Ventricular/ethnology, Hypertrophy, Left Ventricular/genetics, Male, Middle Aged, Phenotype, Regression Analysis
Pubmed
Web of science
Création de la notice
15/03/2011 12:41
Dernière modification de la notice
03/03/2018 18:25
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