Robust T1-Weighted Structural Brain Imaging and Morphometry at 7T Using MP2RAGE.

Détails

Ressource 1Télécharger: BIB_767F69B5FFE9.P001.pdf (6565.49 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_767F69B5FFE9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Robust T1-Weighted Structural Brain Imaging and Morphometry at 7T Using MP2RAGE.
Périodique
Plos One
Auteur(s)
O'Brien K.R., Kober T., Hagmann P., Maeder P., Marques J., Lazeyras F., Krueger G., Roche A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2014
Volume
9
Numéro
6
Pages
e99676
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
PURPOSE: To suppress the noise, by sacrificing some of the signal homogeneity for numerical stability, in uniform T1 weighted (T1w) images obtained with the magnetization prepared 2 rapid gradient echoes sequence (MP2RAGE) and to compare the clinical utility of these robust T1w images against the uniform T1w images.
MATERIALS AND METHODS: 8 healthy subjects (29.0±4.1 years; 6 Male), who provided written consent, underwent two scan sessions within a 24 hour period on a 7T head-only scanner. The uniform and robust T1w image volumes were calculated inline on the scanner. Two experienced radiologists qualitatively rated the images for: general image quality; 7T specific artefacts; and, local structure definition. Voxel-based and volume-based morphometry packages were used to compare the segmentation quality between the uniform and robust images. Statistical differences were evaluated by using a positive sided Wilcoxon rank test.
RESULTS: The robust image suppresses background noise inside and outside the skull. The inhomogeneity introduced was ranked as mild. The robust image was significantly ranked higher than the uniform image for both observers (observer 1/2, p-value = 0.0006/0.0004). In particular, an improved delineation of the pituitary gland, cerebellar lobes was observed in the robust versus uniform T1w image. The reproducibility of the segmentation results between repeat scans improved (p-value = 0.0004) from an average volumetric difference across structures of ≈6.6% to ≈2.4% for the uniform image and robust T1w image respectively.
CONCLUSIONS: The robust T1w image enables MP2RAGE to produce, clinically familiar T1w images, in addition to T1 maps, which can be readily used in uniform morphometry packages.
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/06/2014 10:42
Dernière modification de la notice
08/05/2019 20:34
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