Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.

Details

Serval ID
serval:BIB_765A9534E629
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.
Journal
Journal of Neuroimmunology
Author(s)
Puttini S., Panaite P.A., Mermod N., Renaud S., Steck A.J., Kuntzer T.
ISSN
1872-8421 (Electronic)
ISSN-L
0165-5728
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
270
Number
1-2
Pages
61-66
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.
Keywords
Adult, Aged, Biological Markers/analysis, Biopsy, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/genetics, Skin, Transcriptome
Pubmed
Web of science
Create date
20/06/2014 17:28
Last modification date
20/08/2019 14:33
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