Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.

Détails

ID Serval
serval:BIB_765A9534E629
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.
Périodique
Journal of Neuroimmunology
Auteur(s)
Puttini S., Panaite P.A., Mermod N., Renaud S., Steck A.J., Kuntzer T.
ISSN
1872-8421 (Electronic)
ISSN-L
0165-5728
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
270
Numéro
1-2
Pages
61-66
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.
Mots-clé
Adult, Aged, Biological Markers/analysis, Biopsy, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/genetics, Skin, Transcriptome
Pubmed
Web of science
Création de la notice
20/06/2014 18:28
Dernière modification de la notice
03/03/2018 18:25
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