Article: article from journal or magazin.
Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.
Journal of Neuroimmunology
Publication types: Journal Article Publication Status: ppublish
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.
Adult, Aged, Biological Markers/analysis, Biopsy, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/genetics, Skin, Transcriptome
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