Article: article from journal or magazin.
Utilisation en tomoscintigraphie d'anticorps monoclonaux radio-marqués pour la détection chez l'homme des cancers digestifs et des cancers médullaires de la thyroïde
Bulletin du Cancer
[Use of tomographic scintigraphy with radio-labelled monoclonal antibodies for detecting human digestive cancers and medullary cancers of the thyroid].
Two 131-Iodine radiolabelled monoclonal antibodies were used to perform tomoscintigraphy in 42 patients: 11 patients bearing medullary thyroid cancers and 19 patients bearing gastrointestinal cancers received an antibody directed against carcino-embryonic antigen; 12 patients bearing gastro-intestinal cancers received an antibody directed against a non circulating antigen expressed by human colorectal cancers cell lines. Tomoscintigraphy is particularly useful for analysing the complex biodistribution of radiolabelled antibodies and the low contrast images encountered in immunoscintigraphy; the problems related to the true positive rate and to the clinical specificity of the method are discussed.
Antibodies, Monoclonal/administration & dosage, Antibodies, Neoplasm/administration & dosage, Antigens, Neoplasm/immunology, Carcinoembryonic Antigen/immunology, Colonic Neoplasms/immunology, Digestive System Neoplasms/radionuclide imaging, Evaluation Studies as Topic, Humans, Iodine Radioisotopes/diagnostic use, Rectal Neoplasms/immunology, Thyroid Neoplasms/radionuclide imaging
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