Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model.

Détails

ID Serval
serval:BIB_763467E00E63
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model.
Périodique
Journal of Virology
Auteur(s)
Ardavin C., Luthi F., Andersson M., Scarpellino L., Martin P., Diggelmann H., Acha-Orbea H.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
71
Numéro
10
Pages
7295-7299
Langue
anglais
Résumé
Mouse mammary tumor virus (MMTV) infects B lymphocytes and expresses a superantigen on the cell surface after integration of its reverse-transcribed genome. Superantigen-dependent B- and T-cell activation becomes detectable 2 to 3 days after infection. We show here that before this event, B cells undergo a polyclonal activation which does not involve massive proliferation. This first phase of B-cell activation is T cell independent. Moreover, during the first phase of activation, when only a small fraction of B cells is infected by MMTV(SW), viral DNA is detected only in activated B cells. Such a B-cell activation is also seen after injection of murine leukemia virus but not after injection of vaccinia virus, despite the very similar kinetics and intensity of the immune response. Since retroviruses require activated target cells to induce efficient infection, these data suggest that the early polyclonal retrovirus-induced target cell activation might play an important role in the establishment of retroviral infections.
Mots-clé
Animals, B-Lymphocytes/immunology, B-Lymphocytes/virology, DNA Replication, DNA, Viral/analysis, DNA, Viral/biosynthesis, Female, Genome, Viral, Kinetics, Lymph Nodes/immunology, Lymph Nodes/virology, Lymphocyte Activation, Mammary Neoplasms, Experimental/immunology, Mammary Neoplasms, Experimental/virology, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred Strains, Mice, Nude, Milk/virology, Retroviridae Infections/immunology, T-Lymphocytes/immunology, T-Lymphocytes/virology, Time Factors, Tumor Virus Infections/immunology, Virus Integration, Virus Replication
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 18:25
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