GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.

Détails

ID Serval
serval:BIB_762B2B505DC8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.
Périodique
Molecular and Cellular Biology
Auteur(s)
Membrez M., Hummler E., Beermann F., Haefliger J.A., Savioz R., Pedrazzini T., Thorens B.
ISSN
0270-7306[print], 0270-7306[linking]
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
26
Numéro
11
Pages
4268-4276
Langue
anglais
Résumé
GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues. GLUT8 is located in an intracellular compartment and does not appear to translocate to the cell surface, except in blastocysts, where insulin has been reported to induce its surface expression. Here, we generated mice with inactivation of the glut8 gene. We showed that expression of GLUT8 was not required for normal embryonic development and that glut8-/- mice had normal postnatal development, glucose homeostasis, and response to mild stress. Adult glut8-/- mice showed increased proliferation of hippocampal cells but no defect in memory acquisition and retention. Absence of GLUT8 from the heart did not alter heart size and morphology but led to an increase in P-wave duration, which was not associated with abnormal Nav1.5 Na+ channel or connexin expression. Thus, absence of GLUT8 expression in the mouse caused complex but mild physiological alterations.
Mots-clé
Animals, Body Weight, Cell Proliferation, Connexins/genetics, Embryonic Development, Gene Targeting, Genotype, Glucose/metabolism, Glucose Transport Proteins, Facilitative/deficiency, Glucose Transport Proteins, Facilitative/genetics, Heart/embryology, Heart/physiology, Hippocampus/cytology, Hippocampus/embryology, Homeostasis/physiology, Mice, Mice, Knockout, Myocardium/cytology, Organ Size, Organogenesis, RNA, Messenger/genetics, RNA, Messenger/metabolism, Sodium Channels/genetics, Xenopus
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 12:43
Dernière modification de la notice
20/08/2019 14:33
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