Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study.

Détails

ID Serval
serval:BIB_7615851778DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study.
Périodique
Obesity
Auteur(s)
Gaborit B., Kober F., Jacquier A., Moro P.J., Flavian A., Quilici J., Cuisset T., Simeoni U., Cozzone P., Alessi M.C., Clément K., Bernard M., Dutour A.
ISSN
1930-739X (Electronic)
ISSN-L
1930-7381
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
20
Numéro
6
Pages
1200-1205
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov' tPublication Status: ppublish
Résumé
Epicardial fat (EF) is an active ectopic fat depot, which has been associated with coronary atherosclerosis, and which could early influence endothelial function. We thus investigated the relationship between EF and endothelium-dependent vasoreactivity of the coronary microcirculation, in highly selected healthy volunteers. Myocardial blood flow (MBF) was determined by measuring coronary sinus flow with velocity-encoded cine magnetic resonance imaging (MRI) at 3T. We measured MBF at baseline and in response to sympathetic stimulation by cold pressor testing (CPT) in 30 healthy volunteers with normal left ventricular (LV) function (age 22 ± 4 years, BMI = 21.3 ± 2.8 kg/m(2)). EF volume was volumetrically assessed by manual delineation on short-axis views. CPT was applied by immersing one foot in ice water for 4 min. Mean EF volume was 56 ± 26 ml and mean LV mass 100 ± 28 g. CPT significantly increased heart rate (HR) by 32 ± 19%, systolic blood pressure by 14 ± 10%, and rate-pressure product by 45 ± 25%, P < 0.0001. The increase in HR, reflecting sympathetic stimulation, was not influenced by sex, age or EF volume. CPT induced a decrease in coronary vascular resistance (135 ± 72 vs. 100 ± 42 mm Hg.ml(-1).min.g, P = 0.0006), and a significant increase in MBF (0.81 ± 0.37 vs. 1.24 ± 0.56 ml.min(-1).g(-1), P < 0.0001). Interestingly, we found a significant negative correlation between EF volume and ΔMBF (r= - 0.40, P = 0.03), which remained significant after adjusting for ΔHR. ΔMBF was also associated with adiponectin (r = 0.41, P = 0.046), but not with waist circumference, BMI, C-reactive protein, lipid or glycemic parameters. In multivariate analysis, adiponectin and EF volume remained both independently associated with ΔMBF. A high EF amount is associated with a lower coronary microvascular response, suggesting that EF could early influence endothelial function.
Mots-clé
Adolescent, Adult, Blood Pressure/physiology, Cold Temperature/diagnostic use, Coronary Artery Disease/etiology, Coronary Artery Disease/physiopathology, Coronary Circulation/physiology, Coronary Vessels/physiology, Endothelium, Vascular/physiology, Female, Humans, Male, Microcirculation/physiology, Pilot Projects, Reproducibility of Results, Ventricular Function, Left/physiology, Young Adult
Pubmed
Web of science
Création de la notice
22/02/2015 10:27
Dernière modification de la notice
03/03/2018 18:24
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