Article: article from journal or magazin.
HTPSELEX--a database of high-throughput SELEX libraries for transcription factor binding sites.
Nucleic Acids Research
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
HTPSELEX is a public database providing access to primary and derived data from high-throughput SELEX experiments aimed at characterizing the binding specificity of transcription factors. The resource is primarily intended to serve computational biologists interested in building models of transcription factor binding sites from large sets of binding sequences. The guiding principle is to make available all information that is relevant for this purpose. For each experiment, we try to provide accurate information about the protein material used, details of the wet lab protocol, an archive of sequencing trace files, assembled clone sequences (concatemers) and complete sets of in vitro selected protein-binding tags. In addition, we offer in-house derived binding sites models. HTPSELEX also offers reasonably large SELEX libraries obtained with conventional low-throughput protocols. The FTP site contains the trace archives and database flatfiles. The web server offers user-friendly interfaces for viewing individual entries and quality-controlled download of SELEX sequence libraries according to a user-defined sequencing quality threshold. HTPSELEX is available from ftp://ftp.isrec.isb-sib.ch/pub/databases/htpselex/ and http://www.isrec.isb-sib.ch/htpselex.
Binding Sites, Computational Biology, DNA/chemistry, DNA/metabolism, Databases, Nucleic Acid, Internet, Regulatory Sequences, Nucleic Acid, SELEX Aptamer Technique, Sequence Analysis, DNA, Transcription Factors/metabolism, User-Computer Interface
Web of science
Last modification date