Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome.
Details
Serval ID
serval:BIB_75C4A666BF7F
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome.
Journal
European journal of haematology
ISSN
0902-4441 (Print)
ISSN-L
0902-4441
Publication state
Published
Issued date
03/2006
Peer-reviewed
Oui
Volume
76
Number
3
Pages
255-257
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
A 64-yr-old patient with myelodysplastic syndrome (MDS), with refractory cytopenia with multilineage dysplasia subtype following chloramphenicol exposure received immunosuppressive treatment with antithymocyte globulin and cyclosporine (CsA). Complete remission was achieved and CsA was tapered after 2.5 yr. Shortly after CsA withdrawal, the patient relapsed with thrombocytopenia but responded to restoration of CsA. This case illustrates that immune-mediated mechanisms of cytopenia in MDS may be dependent on continued immunosuppressive treatment similar to aplastic anemia.
Keywords
Chloramphenicol/adverse effects, Cyclosporine/therapeutic use, Humans, Immunosuppressive Agents/therapeutic use, Middle Aged, Myelodysplastic Syndromes/chemically induced, Myelodysplastic Syndromes/complications, Myelodysplastic Syndromes/diagnosis, Pancytopenia/immunology, Platelet Count, Thrombocytopenia/drug therapy, Thrombocytopenia/etiology
Pubmed
Web of science
Create date
01/11/2019 11:36
Last modification date
02/11/2019 7:26
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