Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder.

Détails

Ressource 1Télécharger: BIB_75AC07147F0A.P001.pdf (478.30 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_75AC07147F0A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder.
Périodique
Journal of Psychiatry and Neuroscience : Jpn
Auteur(s)
Haller S., Xekardaki A., Delaloye C., Canuto A., Lövblad K.O., Gold G., Giannakopoulos P.
ISSN
1488-2434 (Electronic)
ISSN-L
1180-4882
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
36
Numéro
6
Pages
391-401
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Background: Previous magnetic resonance imaging (MRI) studies in young patients with bipolar disorder indicated the presence of grey matter concentration changes as well as microstructural alterations in white matter in various neocortical areas and the corpus callosum. Whether these structural changes are also present in elderly patients with bipolar disorder with long-lasting clinical evolution remains unclear. Methods: We performed a prospective MRI study of consecutive elderly, euthymic patients with bipolar disorder and healthy, elderly controls. We conducted a voxel-based morphometry (VBM) analysis and a tract-based spatial statistics (TBSS) analysis to assess fractional anisotropy and longitudinal, radial and mean diffusivity derived by diffusion tensor imaging (DTI). Results: We included 19 patients with bipolar disorder and 47 controls in our study. Fractional anisotropy was the most sensitive DTI marker and decreased significantly in the ventral part of the corpus callosum in patients with bipolar disorder. Longitudinal, radial and mean diffusivity showed no significant between-group differences. Grey matter concentration was reduced in patients with bipolar disorder in the right anterior insula, head of the caudate nucleus, nucleus accumbens, ventral putamen and frontal orbital cortex. Conversely, there was no grey matter concentration or fractional anisotropy increase in any brain region in patients with bipolar disorder compared with controls. Limitations: The major limitation of our study is the small number of patients with bipolar disorder. Conclusion: Our data document the concomitant presence of grey matter concentration decreases in the anterior limbic areas and the reduced fibre tract coherence in the corpus callosum of elderly patients with long-lasting bipolar disorder.
Pubmed
Web of science
Création de la notice
25/10/2011 9:41
Dernière modification de la notice
03/03/2018 18:24
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