Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Case of drug interaction?
Acta Gastro-enterologica Belgica
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
The case of a patient under tibolone therapy for two years who developed a mixed-type liver injury with prolonged cholestasis and features of the vanishing bile duct syndrome following a ten weeks treatment with St. John wort (Hypericum Perforatum) infusions is reported. In the absence of evidence of a potential role for concomitant medication i.e. hydroxychloroquine sulfate to play a role in the clinical, biochemical and morphological picture, an interaction between the herbal preparation and tibolone was suspected as the likely cause of liver damage.
Androgen Antagonists/adverse effects, Bile Ducts, Intrahepatic/drug effects, Bile Ducts, Intrahepatic/pathology, Cholestasis/chemically induced, Drug Interactions, Drug-Induced Liver Injury/etiology, Female, Humans, Hypericum/adverse effects, Middle Aged, Norpregnenes/adverse effects, Postmenopause
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