Leptin and smoking cessation: secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation.

Détails

Ressource 1Télécharger: BIB_7578AE515EB4.P001.pdf (358.25 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_7578AE515EB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Leptin and smoking cessation: secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation.
Périodique
Bmc Public Health
Auteur(s)
Gonseth S., Locatelli I., Bize R., Nusslé S., Clair C., Pralong F., Cornuz J.
ISSN
1471-2458 (Electronic)
ISSN-L
1471-2458
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
14
Numéro
1
Pages
911
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
BACKGROUND: Smokers have a lower body weight compared to non-smokers. Smoking cessation is associated with weight gain in most cases. A hormonal mechanism of action might be implicated in weight variations related to smoking, and leptin might be implicated. We made secondary analyses of an RCT, with a hypothesis-free exploratory approach to study the dynamic of leptin following smoking cessation.
METHODS: We measured serum leptin levels among 271 sedentary smokers willing to quit who participated in a randomized controlled trial assessing a 9-week moderate-intensity physical activity intervention as an aid for smoking cessation. We adjusted leptin for body fat levels. We performed linear regressions to test for an association between leptin levels and the study group over time.
RESULTS: One year after smoking cessation, the mean serum leptin change was +3.23 mg/l (SD 4.89) in the control group and +1.25 mg/l (SD 4.86) in the intervention group (p of the difference < 0.05). When adjusted for body fat levels, leptin was higher in the control group than in the intervention group (p of the difference < 0.01). The mean weight gain was +2.91 (SD 6.66) Kg in the intervention and +3.33 (SD 4.47) Kg in the control groups, respectively (p not significant).
CONCLUSIONS: Serum leptin levels significantly increased after smoking cessation, in spite of substantial weight gain. The leptin dynamic might be different in chronic tobacco users who quit smoking, and physical activity might impact the dynamic of leptin in such a situation.
CLINICAL TRIAL REGISTRATION NUMBER: NCT00521391.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2014 17:24
Dernière modification de la notice
20/08/2019 14:32
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