Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_7569DD148480
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland.
Journal
BMJ open
Author(s)
Boudon A., Locatelli I., Gencer B., Carballo D., Klingenberg R., Räber L., Windecker S., Rodondi N., Lüscher T., Matter C.M., Mach F., Muller O., Nanchen D.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
15/01/2025
Peer-reviewed
Oui
Volume
15
Number
1
Pages
e088262
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: epublish
Abstract
To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).
Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.
Four university hospital centres in Switzerland.
2274 patients with a main diagnosis of ACS between 2009 and 2017 who were available for a 1-year follow-up visit 1 year after hospital discharge.
Self-reported physical activity was assessed with the International Physical Activity Questionnaire. The level of physical activity in metabolic equivalent-minutes per week (MET-min/week) was first stratified into sedentary and physically active categories and then analysed continuously among physically active patients. Analyses were performed using a propensity score weighting approach.
One year after ACS, 1222 (53.7%) patients were on high-intensity statin therapy, 890 (39.1%) were on low/moderate-intensity statin therapy and 162 (7.1%) were not on statin therapy. Compared with non-statin users, low-/moderate-intensity statin users and high-intensity statin users were more likely to be physically active than sedentary, with a fully adjusted OR of 2.86 (95% CI 1.12 to 7.26) and 4.52 (95% CI 1.68 to 12.20), respectively. Among physically active patients, physical activity level was similar across all statin user categories, with median levels of 2792.5, 2712.0 and 2839.5 MET-min/week in non-statin, moderate/low-statin and high-statin users, respectively (p=0.307).
One year after ACS, neither low-/moderate-intensity nor high-intensity statin uses were associated with reduced self-reported physical activity compared with non-statin use. The concern that statin therapy may impair physical activity among ACS patients was not confirmed in this study.
Keywords
Humans, Acute Coronary Syndrome/drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Male, Female, Switzerland, Prospective Studies, Exercise, Middle Aged, Aged, Self Report, Cardiovascular Disease, Coronary heart disease, Drug Therapy, Observational Study, PREVENTIVE MEDICINE
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2025 10:50
Last modification date
04/02/2025 7:25
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