Meningococcal disease in a kidney transplant recipient with mannose-binding lectin (MBL) deficiency

Détails

ID Serval
serval:BIB_754FE5F3037A
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Meningococcal disease in a kidney transplant recipient with mannose-binding lectin (MBL) deficiency
Titre de la conférence
12th International Society for infectious Diseases
Auteur(s)
Manuel O., Tarr R., Venetz J.P., Trandelenburg M., Meylan P., Pascual M.
Adresse
Lisbon, Portugal, June 15-18, 2006
ISBN
1201-9712
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
10
Série
International Journal of Infectious Diseases
Pages
S16
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Background: There is an increasing amount of
data associating MBL deficiency with a higher susceptibility
to meningococca[ disease. In addition,
meningococca[ disease has been reported in patients
with various immunosuppressive conditions.
However, to our knowledge, only three cases of
meningococca[ disease have been reported in solid
organ recipients (SOT).
Methods & Results: A 32 year-old male patient underwent
cadaveric kidney transplantation for endstage
renal disease of unknown origin. On day 71
post-transplantation he developed fever (39.6°C),
shaking chilis, and tachycardia without hypotension.
At this time, immunosuppression consisted
of tacro[imus, prednisone 10mg daily and mycopheno[
ate mofeti[ 2 g daily. Physical examination
on admission was normal, except for two small
petechia[ lesions on the forearm. No meningeal
signs were present. Three sets of blood cultures
grew Neisseria meningitidis group C susceptible to
ceftriaxone (MIC=0.003mg/[). Antibiotic therapy
consisted in intravenous ceftriaxone 2 g per day for
a total duration of 7 days. Serum immunog[obu[in
levels, C3, C4 and CHS0 were normal However, using
a method to screen for the functional activity of
a[[ three pathways of complement (Wies[ab, Lund,
Sweden), no activation via the MBL pathway could
be detected (0%). A subsequent quantification of
MBL pathway components revealed normal levels
of MASP 2 but undetectab[e amounts of MBL (below
10 ng/m[, normal range: >500 ng/m[).
Conclusion: Since the exact incidence and the possible
relationship between meningococca[ disease
and organ transplantation is not we[[ understood,
we strongly encourage transplantation centers to
report additional cases. The potential clinical usefu[
ness of screening SOT candidates for MBL deficiency
in relation to infectious complications after
transplantation remains to be determined.
Mots-clé
,
Web of science
Création de la notice
05/01/2011 11:59
Dernière modification de la notice
03/03/2018 18:23
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