A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group.
Details
Serval ID
serval:BIB_754C6766BB0B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group.
Journal
Neurology
ISSN
0028-3878 (Print)
ISSN-L
0028-3878
Publication state
Published
Issued date
1998
Volume
51
Number
2
Pages
583-586
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.
Keywords
Adult, Amyotrophic Lateral Sclerosis/drug therapy, Double-Blind Method, Europe, Humans, Insulin-Like Growth Factor I/therapeutic use, Recombinant Proteins/therapeutic use
Pubmed
Web of science
Create date
13/01/2014 17:01
Last modification date
20/08/2019 14:32
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