Three-dimensional patient-specific dosimetry in radioimmunotherapy with 90Y-ibritumomab-tiuxetan.

Détails

ID Serval
serval:BIB_754917651287
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Three-dimensional patient-specific dosimetry in radioimmunotherapy with 90Y-ibritumomab-tiuxetan.
Périodique
Cancer Biotherapy and Radiopharmaceuticals
Auteur(s)
D'Arienzo M., Cicone F., Chiacchiararelli L., Coniglio A., Delaloye A.B., Scopinaro F.
ISSN
1557-8852 (Electronic)
ISSN-L
1084-9785
Statut éditorial
Publié
Date de publication
2012
Volume
27
Numéro
2
Pages
124-133
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. Document Type WOS: Article. PDF type d'article: pas d'indication.
Résumé
Aim of the present article was to perform three-dimensional (3D) single photon emission tomography-based dosimetry in radioimmunotherapy (RIT) with (90)Y-ibritumomab-tiuxetan. A custom MATLAB-based code was used to elaborate 3D images and to compare average 3D doses to lesions and to organs at risk (OARs) with those obtained with planar (2D) dosimetry. Our 3D dosimetry procedure was validated through preliminary phantom studies using a body phantom consisting of a lung insert and six spheres with various sizes. In phantom study, the accuracy of dose determination of our imaging protocol decreased when the object volume decreased below 5 mL, approximately. The poorest results were obtained for the 2.58 mL and 1.30 mL spheres where the dose error evaluated on corrected images with regard to the theoretical dose value was -12.97% and -18.69%, respectively. Our 3D dosimetry protocol was subsequently applied on four patients before RIT with (90)Y-ibritumomab-tiuxetan for a total of 5 lesions and 4 OARs (2 livers, 2 spleens). In patient study, without the implementation of volume recovery technique, tumor absorbed doses calculated with the voxel-based approach were systematically lower than those calculated with the planar protocol, with average underestimation of -39% (range from -13.1% to -62.7%). After volume recovery, dose differences reduce significantly, with average deviation of -14.2% (range from -38.7.4% to +3.4%, 1 overestimation, 4 underestimations). Organ dosimetry in one case overestimated, in the other underestimated the dose delivered to liver and spleen. However, both for 2D and 3D approach, absorbed doses to organs per unit administered activity are comparable with most recent literature findings.
Mots-clé
Antibodies, Monoclonal/pharmacokinetics, Antibodies, Monoclonal/therapeutic use, Humans, Imaging, Three-Dimensional/methods, Monte Carlo Method, Neoplasms/metabolism, Neoplasms/radionuclide imaging, Phantoms, Imaging, Radioimmunotherapy/methods, Radiometry/methods, Radiotherapy Planning, Computer-Assisted, Tissue Distribution/radiation effects, Tomography, Emission-Computed, Single-Photon/methods, Yttrium Radioisotopes/pharmacokinetics, Yttrium Radioisotopes/therapeutic use
Pubmed
Web of science
Création de la notice
25/02/2013 11:37
Dernière modification de la notice
03/03/2018 18:23
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