The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study.

Mocroft, A.; Miro, J.M.; Wandeler, G.; Llibre, J.M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J.P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.

doi:10.1111/hiv.13210

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study.

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Serval ID

serval:BIB_7542D67528C1

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study.

Journal

HIV medicine

Author(s)

Mocroft A., Miro J.M., Wandeler G., Llibre J.M., Boyd A., van Bremen K., Beniowski M., Mikhalik J., Cavassini M., Maltez F., Duvivier C., Uberti Foppa C., Knysz B., Bakowska E., Kuzovatova E., Domingo P., Zagalo A., Viard J.P., Degen O., Milinkovic A., Benfield T., Peters L.

Working group(s)

EuroSIDA study group

Contributor(s)

Harxhi A., Losso M., Kundro M., Schmied B., Zangerle R., Karpov I., Vassilenko A., Mitsura V.M., Paduto D., Clumeck N., De Wit S., Delforge M., Florence E., Vandekerckhove L., Hadziosmanovic V., Begovac J., Machala L., Sedlacek D., Kronborg G., Gerstoft J., Katzenstein T., Pedersen C., Johansen I.S., Ostergaard L., Wiese L., Moller N.F., Nielsen L.N., Zilmer K., Smidt J., Aho I., Lacombe K., Pradier C., Fontas E., Rockstroh J., Behrens G., Hoffmann C., Stellbrink H.J., Stefan C., Bogner J., Fätkenheuer G., Chkhartishvili N., Sambatakou H., Adamis G., Paissios N., Szlávik J., Gottfredsson M., Devitt E., Tau L., Turner D., Burke M., Shahar E., Wattad L.M., Elinav H., Haouzi M., Elbirt D., D'Arminio Monforte A., Esposito R., Mazeu I., Mussini C., Mazzotta F., Gabbuti A., Lazzarin A., Castagna A., Gianotti N., Galli M., Ridolfo A., Uzdaviniene V., Matulionyte R., Staub T., Hemmer R., Dragas S., Stevanovic M., Vd Valk M., Trajanovska J., Reikvam D.H., Maeland A., Bruun J., Szetela B., Inglot M., Flisiak R., Grzeszczuk A., Parczewski M., Maciejewska K., Aksak-Was B., Mularska E., Jablonowska E., Kamerys J., Wojcik K., Mozer-Lisewska I., Rozplochowski B., Mansinho K., Radoi R., Oprea C., Gusev D., Trofimova T., Khromova I., Borodulina E., Ranin J., Tomazic J., Miró J.M., Laguno M., Martinez E., Garcia F., Blanco J.L., Martinez-Rebollar M., Mallolas J., Callau P., Rojas J., Inciarta A., Moreno S., Del Campo S., Clotet B., Jou A., Paredes R., Puig J., Santos J.R., Gutierrez M., Mateo G., Sambeat M.A., Laporte J.M., Svedhem V., Thalme A., Sönnerborg A., Brännström J., Flamholc L., Kusejko K., Braun D., Calmy A., Furrer H., Battegay M., Schmid P., Kuznetsova A., Sluzhynska M., Johnson A.M., Simons E., Edwards S., Phillips A., Johnson M.A., Orkin C., Winston A., Clarke A., Leen C., Karpov I., Losso M., Lundgren J., Rockstroh J., Aho I., Rasmussen L.D., Svedhem V., Pradier C., Chkhartishvili N., Matulionyte R., Oprea C., Kowalska J.D., Begovac J., Miró J.M., Guaraldi G., Paredes R., Paredes R., Larsen J.F., Bojesen A., Neesgaard B., Jaschinski N., Fursa O., Sather M., Raben D., Hansen E.V., Kristensen D., Fischer A.H., Jensen S.K., Elsing T.W., Phillips A., Reekie J., Cozzi-Lepri A., Amele S., Pelchen-Matthews A., Roen A., Tusch E.S., Bannister W.

ISSN

1468-1293 (Electronic)

ISSN-L

1464-2662

Publication state

Published

Issued date

07/2022

Peer-reviewed

Oui

Volume

Number

Pages

585-598

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH).
All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit.
Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94-8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47-12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00-1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00-1.89) and NHL (aIRR 2.57; 95% CI 1.16-5.68). There was no significant association between HBV and lung or anal cancer.
We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.

Keywords

DNA, Viral, HIV Infections/complications, Hepatitis B/complications, Hepatitis B/epidemiology, Hepatitis B Surface Antigens, Hepatitis B virus/genetics, Hepatitis B, Chronic/complications, Hepatitis B, Chronic/epidemiology, Humans, Neoplasms/complications, HBV DNA, hepatitis B, nonliver cancer

OAI-PMH

oai:serval.unil.ch:BIB_7542D67528C1

DOI

10.1111/hiv.13210

Pubmed

34889022

Web of science

000728470000001

Open Access

Yes

Create date

17/12/2021 17:30