Tumor Landscapes: β-Catenin Drives Immune Desertification.

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Serval ID
serval:BIB_7529A1E77088
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Tumor Landscapes: β-Catenin Drives Immune Desertification.
Journal
Clinical cancer research
Author(s)
Dangaj D. (co-first), Barras D. (co-first), Coukos G.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Publication state
Published
Issued date
15/05/2019
Peer-reviewed
Oui
Volume
25
Number
10
Pages
2943-2945
Language
english
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Abstract
Immune checkpoint blockade therapy requires a preestablished activated immune landscape. Understanding tumor-intrinsic mechanisms that lead to T-cell desertification is key to resensitizing them to such therapies. The WNT/β-catenin tumor-intrinsic signaling is emerging as an immune exclusion pathway that holds high promise to counteract resistance to immunotherapy.See related article by Luke et al., p. 3074.
Keywords
Conservation of Natural Resources, Humans, Immunotherapy, Neoplasms/immunology, Wnt Signaling Pathway, beta Catenin/immunology
OAI-PMH
oai:serval.unil.ch:BIB_7529A1E77088
DOI
10.1158/1078-0432.CCR-19-0188
Pubmed
30837277
Web of science
000468064200001
Create date
07/04/2019 14:05
Last modification date
29/04/2023 5:51
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