Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_75081EC3933E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol.
Journal
F1000Research
Author(s)
Appenzeller-Herzog C., Hartleif S., Vionnet J.
ISSN
2046-1402 (Electronic)
ISSN-L
2046-1402
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
8
Pages
2059
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in paediatric or adult non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form.
Keywords
Adult, Biomarkers, Child, Humans, Immunosuppression/methods, Liver Transplantation, Research Design, Review Literature as Topic, Transplantation Tolerance, Tregs, biomarker, clinical parameter, flow cytometry, gene expression profiling, immunosuppression, immunosuppression withdrawal, liver biopsy, liver transplantation, operational tolerance, regulatory lymphocytes, scoping review
Pubmed
Web of science
Open Access
Yes
Create date
03/07/2020 17:00
Last modification date
12/01/2022 8:11
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