Uric acid transport and disease.

Détails

ID Serval
serval:BIB_74F7918F742F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Uric acid transport and disease.
Périodique
Journal of Clinical Investigation
Auteur(s)
So A., Thorens B.
ISSN
1558-8238[electronic], 0021-9738[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
120
Numéro
6
Pages
1791-1799
Langue
anglais
Résumé
Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.
Mots-clé
Animals, Biological Transport/genetics, Glucose Transport Proteins, Facilitative/genetics, Glucose Transport Proteins, Facilitative/metabolism, Gout/etiology, Gout/genetics, Humans, Hypertension/complications, Hypertension/genetics, Hyperuricemia/etiology, Hyperuricemia/genetics, Uric Acid/blood, Uric Acid/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/06/2010 12:49
Dernière modification de la notice
20/08/2019 14:32
Données d'usage