Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.

Détails

ID Serval
serval:BIB_74CEF758ED66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
Périodique
Genes and Development
Auteur(s)
Moye-Rowley W.S., Harshman K.D., Parker C.S.
ISSN
0890-9369 (Print)
ISSN-L
0890-9369
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
3
Numéro
3
Pages
283-292
Langue
anglais
Résumé
The jun family of transcriptional activators includes mammalian AP-1 as well as the yeast regulatory protein GCN4. Recently, an additional transcriptional activator has been found in yeast that recognizes the TGACTCA sequence element common in GCN4/AP-1 sites. This factor was designated yAP-1. The structural gene for yAP-1 has now been isolated and characterized. The deduced amino acid sequence predicts a protein of 650 residues, considerably larger than GCN4 or c-Jun. The amino terminus of yAP-1 is homologous to the carboxy-terminal DNA-binding domains of GCN4 and c-Jun. Disruption of the YAP1 gene demonstrates this gene is not essential but is required for AP-1 recognition element-dependent transcriptional activation. DNA-affinity blots of proteins from YAP1 cells suggest the presence of additional TGACTCA-binding proteins other than GCN4 and yAP-1. Furthermore, expression of at least one of these related DNA-binding proteins appears to be under control of yAP-1.
Mots-clé
Amino Acid Sequence, Base Sequence, Binding Sites, Cloning, Molecular, DNA, Fungal, Endonucleases, Fungal Proteins/genetics, Genes, Fungal, Molecular Sequence Data, Mutation, Proto-Oncogene Proteins/genetics, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae Proteins, Single-Strand Specific DNA and RNA Endonucleases, Transcription Factors/genetics
Pubmed
Web of science
Création de la notice
12/03/2008 13:40
Dernière modification de la notice
03/03/2018 18:22
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