Clearance of ceftriaxone during haemodialysis using cuprophane, haemophane and polysulfone dialysers.
Details
Serval ID
serval:BIB_74C70DC21F4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clearance of ceftriaxone during haemodialysis using cuprophane, haemophane and polysulfone dialysers.
Journal
European Journal of Clinical Pharmacology
ISSN
0031-6970 (Print)
ISSN-L
0031-6970
Publication state
Published
Issued date
1997
Volume
53
Number
2
Pages
123-126
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: The purpose of the present study was to investigate whether the clearance of ceftriaxone during haemodialysis is influenced by the type of membrane used (cuprophane, haemophane or polysulphone).
METHODS: After administration of a single 2-g dose of ceftriaxone, the half-life of the drug during haemodialysis and the clearance of the dialyser were measured.
RESULTS: The mean dialysis clearance normalised for square metre of membrane surface was significantly different for the three dialysers (haemophane 24 ml.min-1.m-2; cuprophane 32 ml.min-1.m-2; polysulphone 42 ml.min-1.m-2).
CONCLUSIONS: Polysulphone membranes are more permeable and increase the extraction of ceftriaxone more than the other dialysers studied (haemophane and cuprophane membranes). These results, taken together with previous data, show that an increase of the dose in dialysis patients treated with large surface (> 0.8 m2) and high permeability membranes might be necessary.
METHODS: After administration of a single 2-g dose of ceftriaxone, the half-life of the drug during haemodialysis and the clearance of the dialyser were measured.
RESULTS: The mean dialysis clearance normalised for square metre of membrane surface was significantly different for the three dialysers (haemophane 24 ml.min-1.m-2; cuprophane 32 ml.min-1.m-2; polysulphone 42 ml.min-1.m-2).
CONCLUSIONS: Polysulphone membranes are more permeable and increase the extraction of ceftriaxone more than the other dialysers studied (haemophane and cuprophane membranes). These results, taken together with previous data, show that an increase of the dose in dialysis patients treated with large surface (> 0.8 m2) and high permeability membranes might be necessary.
Keywords
Adult, Aged, Biocompatible Materials, Ceftriaxone/blood, Ceftriaxone/pharmacokinetics, Cellulose/analogs & derivatives, Cephalosporins/blood, Cephalosporins/pharmacokinetics, Chromatography, High Pressure Liquid, Female, Half-Life, Humans, Male, Membranes, Artificial, Metabolic Clearance Rate, Middle Aged, Polymers, Renal Dialysis/instrumentation, Sulfones
Pubmed
Create date
19/06/2013 12:19
Last modification date
16/04/2020 6:26
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