Psychogenic seizures and frontal disconnection: EEG synchronisation study.

Détails

ID Serval
serval:BIB_74B2B36D7E97
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Psychogenic seizures and frontal disconnection: EEG synchronisation study.
Périodique
Journal of Neurology, Neurosurgery, and Psychiatry
Auteur(s)
Knyazeva M.G., Jalili M., Frackowiak R.S., Rossetti A.O.
ISSN
1468-330X (Electronic)
ISSN-L
0022-3050
Statut éditorial
Publié
Date de publication
2011
Volume
82
Numéro
5
Pages
505-511
Langue
anglais
Résumé
Objective Psychogenic non-epileptic seizures (PNES) are paroxysmal events that, in contrast to epileptic seizures, are related to psychological causes without the presence of epileptiform EEG changes. Recent models suggest a multifactorial basis for PNES. A potentially paramount, but currently poorly understood factor is the interplay between psychiatric features and a specific vulnerability of the brain leading to a clinical picture that resembles epilepsy. Hypothesising that functional cerebral network abnormalities may predispose to the clinical phenotype, the authors undertook a characterisation of the functional connectivity in PNES patients. Methods The authors analysed the whole-head surface topography of multivariate phase synchronisation (MPS) in interictal high-density EEG of 13 PNES patients as compared with 13 age- and sex-matched controls. MPS mapping reduces the wealth of dynamic data obtained from high-density EEG to easily readable synchronisation maps, which provide an unbiased overview of any changes in functional connectivity associated with distributed cortical abnormalities. The authors computed MPS maps for both Laplacian and common-average-reference EEGs. Results In a between-group comparison, only patchy, non-uniform changes in MPS survived conservative statistical testing. However, against the background of these unimpressive group results, the authors found widespread inverse correlations between individual PNES frequency and MPS within the prefrontal and parietal cortices. Interpretation PNES appears to be associated with decreased prefrontal and parietal synchronisation, possibly reflecting dysfunction of networks within these regions.
Pubmed
Web of science
Création de la notice
26/04/2011 15:24
Dernière modification de la notice
03/03/2018 18:22
Données d'usage