Identification and characterization of an anti-tyrosine kinase factor in cystic gliomas

Détails

ID Serval
serval:BIB_74B003D560C3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification and characterization of an anti-tyrosine kinase factor in cystic gliomas
Périodique
FEBS Letters
Auteur(s)
Berger  F., Laine  M., Amalfitano  G., Brunet  J. F., Verna  J. M., Nissou  M. F., Benabid  A. L.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
01/1993
Peer-reviewed
Oui
Volume
316
Numéro
2
Pages
147-51
Notes
Journal Article --- Old month value: Jan 25
Résumé
In view of the frequent activation of the epidermal growth factor receptor (EGF-R) in gliomas and autocrine hypothesis, we searched for 'EGF-like' factor(s) in cystic fluids (CFs) associated with gliomas. Membranes of A431 cells, which overexpress EGF-R, were used to explore such activity in 20 CFs. In all cases CFs induced inhibition of EGF-R phosphorylation. Biochemical analysis revealed an anti-tyrosine kinase activity which was identified as a 18 kDa proteic factor. Effectiveness at high dilution and anti-proliferative effect on living cells in culture suggest that this factor may be involved in the negative regulation of glial oncogenesis.
Mots-clé
Astrocytoma/*chemistry Brain Neoplasms/*chemistry Chromatography, High Pressure Liquid Electrophoresis, Polyacrylamide Gel Humans Phosphorylation Protein-Tyrosine Kinases/*antagonists & inhibitors Receptor, Epidermal Growth Factor/metabolism Tumor Cells, Cultured
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/02/2008 10:44
Dernière modification de la notice
08/05/2019 20:28
Données d'usage