Vitamin D status and functional performance in peripheral artery disease.
Details
Serval ID
serval:BIB_74A3D8EFA63F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamin D status and functional performance in peripheral artery disease.
Journal
Vascular medicine
ISSN
1477-0377 (Electronic)
ISSN-L
1358-863X
Publication state
Published
Issued date
10/2012
Peer-reviewed
Oui
Volume
17
Number
5
Pages
294-302
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Abstract
The clinical implications of low vitamin D in peripheral artery disease (PAD) are unknown. We hypothesized that among individuals with PAD, lower levels of 25-hydroxyvitamin D would be associated with poorer functional performance, more adverse calf muscle characteristics, and poorer peripheral nerve function. Participants were 402 men and women with PAD who underwent measurement of 25-hydroxyvitamin D (DiaSorin radioimmunoassay) along with 6-minute walk testing, measurement of walking velocity at usual and fastest pace, computed tomography-measured calf muscle density, and peripheral nerve conduction velocity (NCV). Among PAD participants, 20.4% had 25-hydroxyvitamin D levels < 30 nmol/L, consistent with deficient vitamin D status. Adjusting for age, sex, and race, lower 25-hydroxyvitamin D levels were associated with poorer 6-minute walk performance (p trend = 0.002), slower usual-paced 4-meter walking velocity (p trend = 0.031), slower fast-paced 4-meter walking velocity (p trend = 0.043), and lower calf muscle density (p trend = 0.031). After additional adjustment for body mass index (BMI) and diabetes, none of these associations remained statistically significant. However, lower levels of 25-hydroxyvitamin D were associated with poorer peroneal NCV (p trend = 0.013) and poorer sural NCV (p trend = 0.039), even after adjusting for age, sex, race, BMI, comorbidities, smoking, physical activity, and other confounders. In conclusion, vitamin D deficiency is common among people with PAD encountered in clinical settings. After adjusting for BMI and diabetes mellitus, we found no significant associations of lower levels of 25-hydroxyvitamin D with poorer functional performance or calf muscle characteristics. Associations of low vitamin D levels with poorer peripheral nerve function require further study.
Keywords
Aged, Aged, 80 and over, Ankle Brachial Index, Biomarkers/blood, Chi-Square Distribution, Chicago/epidemiology, Cross-Sectional Studies, Down-Regulation, Exercise Test, Exercise Tolerance, Female, Humans, Intermittent Claudication/blood, Intermittent Claudication/diagnosis, Intermittent Claudication/epidemiology, Intermittent Claudication/physiopathology, Linear Models, Male, Middle Aged, Multivariate Analysis, Muscle Contraction, Muscle Strength, Muscle, Skeletal/diagnostic imaging, Muscle, Skeletal/innervation, Muscle, Skeletal/physiopathology, Neural Conduction, Peripheral Arterial Disease/blood, Peripheral Arterial Disease/diagnosis, Peripheral Arterial Disease/epidemiology, Peripheral Arterial Disease/physiopathology, Peroneal Nerve/physiopathology, Predictive Value of Tests, Prevalence, Radioimmunoassay, Risk Factors, Sural Nerve/physiopathology, Time Factors, Tomography, X-Ray Computed, Vitamin D/analogs & derivatives, Vitamin D/blood, Vitamin D Deficiency/blood, Vitamin D Deficiency/diagnosis, Vitamin D Deficiency/epidemiology, Vitamin D Deficiency/physiopathology, Walking
Pubmed
Web of science
Create date
28/12/2020 0:08
Last modification date
28/12/2020 7:26