Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

Détails

ID Serval
serval:BIB_74A347CC425D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.
Périodique
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
Auteur(s)
Eperon S., Sauty A., Lanz R., Leimgruber A., Lurati F., Guex-Crosier Y.
ISSN
0721-832X
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
242
Numéro
11
Pages
966-70
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
PURPOSE: To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. METHODS: Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. RESULTS: Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). CONCLUSIONS: The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.
Mots-clé
Adult, Chemokine CCL11, Chemokines, CC, Chemotactic Factors, Eosinophil, Conjunctivitis, Allergic, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Prospective Studies, Seasons, Tears, Up-Regulation
Pubmed
Web of science
Création de la notice
17/01/2008 14:27
Dernière modification de la notice
03/03/2018 18:21
Données d'usage