Tolerance of whitefish embryos to Pseudomonas fluorescens linked to genetic and maternal effects, and reduced by previous exposure.

Détails

ID Serval
serval:BIB_74A31C6D112A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tolerance of whitefish embryos to Pseudomonas fluorescens linked to genetic and maternal effects, and reduced by previous exposure.
Périodique
Fish and Shellfish Immunology
Auteur(s)
von Siebenthal B.A., Jacob A., Wedekind C.
ISSN
1095-9947[electronic]
Statut éditorial
Publié
Date de publication
03/2009
Peer-reviewed
Oui
Volume
26
Numéro
3
Pages
531-535
Langue
anglais
Résumé
Juvenile or adult fish can alter their behaviour and rely on an innate and adaptive immune system to avoid/counteract pathogens, while fish embryos have to depend on egg characteristics and may be partly protected by their developing immune system that is building up from a certain age on. We developed an infection protocol that allows testing the reaction of individual whitefish embryos (Coregonus palaea) to repeated exposures to Pseudomonas fluorescens, an opportunistic bacterial fish pathogen. We used a full-factorial in vitro breeding design to separately test the effects of paternal and maternal contributions to the embryos' susceptibility to different kinds of pathogen exposure. We found that a first non-lethal exposure had immunosuppressive effects: pre-exposed embryos were more susceptible to future challenges with the same pathogen. At intermediate and high levels of pathogen intensity, maternal effects turned out to be crucial for the embryos' tolerance to infection. Paternal (i.e. genetic) effects played a significant role at the strongest level of infection, i.e. the embryos' own genetics already explained some of the variation in embryo susceptibility. Our findings suggest that whitefish embryos are largely protected by maternally transmitted substances, but build up some own innate immunocompetence several days before hatching.
Mots-clé
Animals, Breeding, Embryo, Nonmammalian/microbiology, Fish Diseases/genetics, Fish Diseases/microbiology, Genetic Variation, Pseudomonas Infections/genetics, Pseudomonas Infections/microbiology, Pseudomonas fluorescens/physiology, Salmonidae/genetics, Salmonidae/microbiology
Pubmed
Web of science
Création de la notice
05/02/2009 16:02
Dernière modification de la notice
03/03/2018 18:21
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