Polycyclic aromatic hydrocarbons (PAHs) skin permeation rates change with simultaneous exposures to solar ultraviolet radiation (UV-S).

Détails

Ressource 1Télécharger: 2018_Hopf_PAH_UV_postprint_final.pdf (638.45 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_749CE9A9840F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Polycyclic aromatic hydrocarbons (PAHs) skin permeation rates change with simultaneous exposures to solar ultraviolet radiation (UV-S).
Périodique
Toxicology Letters
Auteur(s)
Hopf Nancy B., Spring Philipp, Hirt-Burri Nathalie, Jimenez Silvia, Sutter Benjamin, Vernez David, Berthet Aurélie
ISSN
1879-3169 (Electronic)
ISSN-L
0378-4274
Statut éditorial
Publié
Date de publication
01/05/2018
Peer-reviewed
Oui
Volume
287
Pages
122-130
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Road construction workers are simultaneously exposed to two carcinogens; solar ultraviolet (UV-S) radiation and polycyclic aromatic hydrocarbons (PAHs) in bitumen emissions. The combined exposure may lead to photogenotoxicity and enhanced PAH skin permeation rates. Skin permeation rates (J) for selected PAHs in a mixture (PAH-mix) or in bitumen fume condensate (BFC) with and without UV-S co-exposures were measured with in vitro flow-through diffusion cells mounted with human viable skin and results compared. Possible biomarkers were explored. Js were greater with UV-S for naphthalene, anthracene, and pyrene in BFC (0.08-0.1 ng/cm javax.xml.bind.JAXBElement@5490394f /h) compared to without (0.02-0.26 ng/cm javax.xml.bind.JAXBElement@2ff08242 /h). This was true for anthracene, pyrene, and chrysene in the PAH-mix. Naphthalene and benzo(a)pyrene (BaP) in the PAH-mix had greater Js without (0.97-13.01 ng/cm javax.xml.bind.JAXBElement@4d9aaf01 /h) compared to with UV-S (0.40-6.35 ng/cm javax.xml.bind.JAXBElement@6fa62fdf /h). Time until permeation (T javax.xml.bind.JAXBElement@3a293925 ) in the PAH-mix were generally shorter compared to the BFC, and they ranged from 1 to 13 h. The vehicle matrix could potentially be the reason for this discrepancy as BFC contains additional not identified substances. Qualitative interpretation of p53 suggested a dose-response with UV-S, and somewhat with the co-exposures. MMP1, p65 and cKIT were not exploitable. Although not statistically different, PAHs permeate human viable skin faster with simultaneous exposures to UV.

Mots-clé
Benzo(a)pyrene/metabolism, Benzo(a)pyrene/toxicity, Biomarkers/metabolism, Diffusion, Diffusion Chambers, Culture, Dose-Response Relationship, Radiation, Humans, Hydrocarbons/metabolism, Hydrocarbons/toxicity, Matrix Metalloproteinase 1/genetics, Matrix Metalloproteinase 1/metabolism, Naphthalenes/metabolism, Naphthalenes/toxicity, Permeability, Polycyclic Aromatic Hydrocarbons/metabolism, Polycyclic Aromatic Hydrocarbons/toxicity, Proto-Oncogene Proteins c-kit/metabolism, Skin/metabolism, Skin/radiation effects, Skin Absorption/radiation effects, Time Factors, Transcription Factors/metabolism, Tumor Suppressor Protein p53/metabolism, Tumor Suppressor Proteins/metabolism, Ultraviolet Rays/adverse effects, Bitumen, Flow-through diffusion cells, Human skin, PAH, Polycyclic aromatic hydrocarbons, Skin exposure, Skin permeation, Solar ultraviolet radiation, UV
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/02/2018 18:36
Dernière modification de la notice
08/05/2019 20:28
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