MR, (18)F-FDG, and (18)F-AV45 PET correlate with AD PSEN1 original phenotype.

Détails

ID Serval
serval:BIB_748DBEED32C1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MR, (18)F-FDG, and (18)F-AV45 PET correlate with AD PSEN1 original phenotype.
Périodique
Alzheimer Disease and Associated Disorders
Auteur(s)
Saint-Aubert L., Payoux P., Hannequin D., Barbeau E.J., Campion D., Delisle M.B., Tafani M., Viallard G., Péran P., Puel M., Chollet F., Demonet J.F., Pariente J.
ISSN
1546-4156 (Electronic)
ISSN-L
0893-0341
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
27
Numéro
1
Pages
91-94
Langue
anglais
Résumé
We report the case of a 37-year-old man suffering from insidious visual agnosia and spastic paraparesis due to a PSEN1 mutation. His mother was diagnosed with Alzheimer disease after a biopsy. He was assessed by multimodal neuroimaging, including new in vivo positron emission tomography amyloid imaging (F-AV45). His data were compared with those from healthy participants and patients with sporadic predemential Alzheimer disease. He exhibited posterior cortical thickness reduction, posterior hypometabolism, and increased amyloid ligand uptake in the posterior cortex and the striatum. We show that F-AV45 positron emission tomography allows visualization of the unusual pattern of amyloid deposits that co-localize with cortical atrophy in this genetic form of Alzheimer disease.
Mots-clé
Alzheimer disease, amyloid, AV45, genetics, MRI, PET
Pubmed
Web of science
Création de la notice
23/03/2013 23:56
Dernière modification de la notice
03/03/2018 18:21
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