Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Mise à jour sur l'hépatite E [An update on hepatitis E].
Revue Médicale Suisse
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
The hepatitis E virus (HEV) is an RNA virus transmitted via the fecal-oral route or through uncooked animal meat products. Of the 4 known genotypes, genotype 3 is responsible for autochthonous infections in industrialized countries, with a seroprevalence in Switzerland estimated as high as 22%. The majority of infections is asymptomatic but a minority of patients, notably men over 50 or with underlying liver disease, can present with severe acute hepatitis. Chronic hepatitis E with HEV of genotype 3 has been observed in immunosuppressed patients, mostly transplant recipients. Serology is not sufficiently sensitive, especially in immunosuppressed patients, making PCR identification the preferred test for diagnosing active infection. Ribavirin or interferon-alpha can be used to treat chronic hepatitis E if reduction of immunosuppressive treatment does not result in viral elimination.
Adolescent, Adult, Age Factors, Antiviral Agents/therapeutic use, Female, Genotype, Hepatitis E/epidemiology, Hepatitis E/therapy, Hepatitis E virus/genetics, Hepatitis E virus/isolation & purification, Humans, Immunocompromised Host, Male, Middle Aged, Risk Factors, Seroepidemiologic Studies, Sex Factors, Switzerland/epidemiology, Young Adult
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