Markers of atherosclerosis and inflammation for prediction of coronary heart disease in older adults.

Détails

ID Serval
serval:BIB_74775F09CF7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Markers of atherosclerosis and inflammation for prediction of coronary heart disease in older adults.
Périodique
American Journal of Epidemiology
Auteur(s)
Rodondi Nicolas, Marques-Vidal Pedro, Butler Javed, Sutton-Tyrrell Kim, Cornuz Jacques, Satterfield Suzanne, Harris Tamara, Bauer Douglas C., Ferrucci Luigi, Vittinghoff Eric, Newman Anne B., Health Aging
Collaborateur(s)
Body Composition Study research group
ISSN
1476-6256[electronic]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
171
Numéro
5
Pages
540-549
Langue
anglais
Résumé
Although both inflammatory and atherosclerosis markers have been associated with coronary heart disease (CHD) risk, data directly comparing their predictive value are limited. The authors compared the value of 2 atherosclerosis markers (ankle-arm index (AAI) and aortic pulse wave velocity (aPWV)) and 3 inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) in predicting CHD events. Among 2,191 adults aged 70-79 years at baseline (1997-1998) from the Health, Aging, and Body Composition Study cohort, the authors examined adjudicated incident myocardial infarction or CHD death ("hard" events) and "hard" events plus hospitalization for angina or coronary revascularization (total CHD events). During 8 years of follow-up between 1997-1998 and June 2007, 351 participants developed total CHD events (197 "hard" events). IL-6 (highest quartile vs. lowest: hazard ratio = 1.82, 95% confidence interval: 1.33, 2.49; P-trend < 0.001) and AAI (AAI </= 0.9 vs. AAI 1.01-1.30: hazard ratio = 1.57, 95% confidence interval: 1.14, 2.18) predicted CHD events above traditional risk factors and modestly improved global measures of predictive accuracy. CRP, TNF-alpha, and aPWV had weaker associations. IL-6 and AAI accurately reclassified 6.6% and 3.3% of participants, respectively (P's </= 0.05). Results were similar for "hard" CHD, with higher reclassification rates for AAI. IL-6 and AAI are associated with future CHD events beyond traditional risk factors and modestly improve risk prediction in older adults.
Mots-clé
Aged , Atherosclerosis/complications , Atherosclerosis/diagnosis* , Biological Markers/metabolism , C-Reactive Protein/metabolism , Cohort Studies , Coronary Disease/epidemiology* , Coronary Disease/etiology , Female , Humans , Inflammation/complications , Inflammation/metabolism* , Interleukin-6/metabolism , Male , Risk Factors , Tumor Necrosis Factor-alpha/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2010 16:09
Dernière modification de la notice
08/05/2019 20:27
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