Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

Détails

ID Serval
serval:BIB_745D2B8C6B51
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
Périodique
The European respiratory journal
Auteur(s)
Cottin V., Bel E., Bottero P., Dalhoff K., Humbert M., Lazor R., Sinico R.A., Sivasothy P., Wechsler M.E., Groh M., Marchand-Adam S., Khouatra C., Wallaert B., Taillé C., Delaval P., Cadranel J., Bonniaud P., Prévot G., Hirschi S., Gondouin A., Dunogué B., Chatté G., Briault A., Jayne D., Guillevin L., Cordier J.F.
Collaborateur(s)
   the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P)
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
48
Numéro
5
Pages
1429-1441
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail.In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease.The study population included 157 patients (mean±sd age 49.4±14.1 years), with a mean±sd blood eosinophil count of 7.4±6.4×10 javax.xml.bind.JAXBElement@6693fb03  L javax.xml.bind.JAXBElement@68dfd280 at diagnosis. There was a mean±sd of 11.8±18.2 years from the onset of asthma to the diagnosis of EGPA, of 1.4±8.4 years from the first onset of peripheral eosinophilia to the diagnosis of EGPA, and of 7.4±6.4 years from EGPA diagnosis to the final visit. Despite inhaled and oral corticosteroid treatment, the severity of asthma increased 3-6 months before the onset of the systemic manifestations. Asthma was severe in 57%, 48%, and 56% of patients at diagnosis, at 3 years, and at the final visit, respectively. Persistent airflow obstruction was present in 38%, 30%, and 46% at diagnosis, at 3 years, and at the final visit, respectively.In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long-term management and morbidity.

Mots-clé
Administration, Oral, Adolescent, Adrenal Cortex Hormones/administration & dosage, Adult, Aged, Aged, 80 and over, Asthma/physiopathology, Bronchoalveolar Lavage, Churg-Strauss Syndrome/complications, Churg-Strauss Syndrome/physiopathology, Eosinophilia/physiopathology, Eosinophils/cytology, Female, France, Granulomatosis with Polyangiitis/complications, Granulomatosis with Polyangiitis/physiopathology, Humans, Male, Middle Aged, Prognosis, Respiratory Function Tests, Retrospective Studies, Severity of Illness Index, Systemic Vasculitis/physiopathology, Tomography, X-Ray Computed, Treatment Outcome, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/09/2016 21:37
Dernière modification de la notice
08/05/2019 20:27
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